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About this product

Elevate your regimen with the clinically proven impact of this two-step set.

Mary Kay Clinical Solutions Retinol 0.5

Powered by pure, high-concentration retinol, this nighttime serum takes the offensive against wrinkles, discoloration and loss of firmness. Retinol is the gold-standard ingredient dermatologists recommend for adults of every age, and it helps prevent signs of aging you can’t see yet, while helping to reverse advanced visible signs of aging.

Mary Kay Clinical Solutions™ Calm + Restore Facial Milk

Clinically proven to calm irritated skin* and deliver instant hydration,* this nourishing facial milk is powered by four plant oils known for their soothing properties. Mary Kay Clinical Solutions™ Calm + Restore Facial Milk is perfect for anyone seeking a lightweight facial milk or as an integral part of our gentle retinization process when used in conjunction with Mary Kay Clinical Solutions™ Retinol 0.5.

*Results based on two independent clinical studies in which women used the Mary Kay Clinical Solutions™ Calm + Restore Facial Milk
Do not use Mary Kay Clinical Solutions™ Retinol 0.5 if you are pregnant, lactating or planning to become pregnant.
This product cannot be shipped to or sold in the Dominican Republic due to local regulations.

 

Mary Kay Clinical Solutions™ Retinol 0.5 Set

Amplify your age-fighting power to new levels. Maximize results with Mary Kay Clinical Solutions™ Retinol 0.5 while minimizing discomfort with the expertly formulated Mary Kay Clinical Solutions™ Calm + Restore Facial Milk.

  • Fragrance-free.
  • Dermatologist-tested.
  • Non-comedogenic.

The next-level dermocosmetic solutions in this set combined with Mary Kay’s unique retinization process delivers proven results. Add this power pair developed by the Mary Kay Research and Innovation Team to your current skin care regimen to experience a superstar ingredient with a soothing counterpart.

“Retinol is considered the foundation of youthful skin. Three decades of clinical research demonstrate its efficacy. We all want skin that looks good. More importantly, we all need healthy, resilient skin that can protect us beautifully throughout our lifetime.”

– Mary Kay Chief Scientific Officer Dr. Lucy Gildea

Dermatologists’ Council Seal

In developing the Mary Kay Clinical Solutions™ line of products, Mary Kay went above and beyond the normal process of safety testing and claims review, providing behind-the-scenes access to an external advisory panel of U.S. board-certified dermatologists to help validate the formula and ingredients. The panel includes dermatologists selected for their extensive skin care expertise, scholarship and professional practice. The panel conducted a thorough review and evaluation of clinical tests, data and/or scientific support for the formula and ingredients.

 

Application Tips

When using a high-concentration retinol product, it is important to gradually establish skin tolerance, also referred to as "retinization," before advancing to more frequent usage. If you are a first-time user of pure retinol,* Mary Kay’s gentle retinization process (below) is recommended for you.

During the retinization process, Mary Kay recommends avoiding physical and chemical exfoliation products, acne products and products with high concentrations of vitamin C since they may contribute to temporary dryness or irritation.

WEEKS 1 2

Apply Mary Kay Clinical Solutions™ Retinol 0.5 1x per week on the same night, diluted with Mary Kay Clinical Solutions™ Calm Restore Facial Milk.

Directions: In the evening, cleanse skin and wait approximately five to ten minutes. Mix a pea-sized amount (one pump) of Mary Kay Clinical Solutions™ Retinol 0.5 with one pump of Mary Kay Clinical Solutions™ Calm Restore Facial Milk. Apply mixture to forehead, cheeks, nose and chin in an upward, outward motion, avoiding the eye area. Allow for full absorption before applying other skin care products. Mary Kay Clinical Solutions™ Calm Restore Facial Milk can also be used throughout the day and week as needed to relieve skin. Use sunscreen during the day.

WEEKS 3 4

Apply Mary Kay Clinical Solutions™ Retinol 0.5 1x per week on the same night, followed by Mary Kay Clinical Solutions™ Calm Restore Facial Milk.

WEEKS 5 6

Apply Mary Kay Clinical Solutions™ Retinol 0.5 2x per week, followed by Mary Kay Clinical Solutions™ Calm Restore Facial Milk, as needed.

WEEKS 7 8

Apply Mary Kay Clinical Solutions™ Retinol 0.5 3x – 5x per week, followed by Mary Kay Clinical Solutions™ Calm Restore Facial Milk, as needed.

WEEKS 9

Continued benefits come with continued usage. Usage frequency of Mary Kay Clinical Solutions™ Retinol 0.5 is based on skin tolerance. Once skin is retinized, product may be used as often as every evening, followed by Mary Kay Clinical Solutions™ Calm Restore Facial Milk as needed.

Click here to learn more about retinol’s compatibility with other ingredients and Mary Kay® products and to find out if retinol is right for you. Do not use Mary Kay Clinical Solutions™ Retinol 0.5 if you are pregnant, lactating or planning to become pregnant.

*TimeWise Repair® products do not contain pure retinol. TimeWise Repair® products contain an encapsulated, controlled-release retinol that’s not designed to retinize your skin. If TimeWise Repair® products are your only source for retinol, Mary Kay recommends following the retinization process to help skin adjust to the potency of the high concentration retinol found in Mary Kay Clinical Solutions™ Retinol 0.5.

 

Key Ingredients

MARY KAY CLINICAL SOLUTIONS™ RETINOL 0.5

Retinol (Vitamin A)

  • Stimulates surface skin cell renewal, so skin appears as it did when you were younger.
  • Supports natural collagen and elastin, improving the appearance of collagen-depleted skin.

MARY KAY CLINICAL SOLUTIONS™ CALM + RESTORE FACIAL MILK

Glycerin

A well-known humectant that attracts and retains water to help boost moisture levels. It is naturally occurring in skin. It not only helps condition skin but also helps give skin a soft, smooth feel.

Plant Oils

Coconut, jojoba seed, safflower and olive oils deliver a power shot of rich fatty acids to nourish and soothe skin.

Squalane

Squalane (-lane) is a hydrogenated form of squalene (-lene), which makes it stable in formula. Squalene and squalane are natural emollients derived from plants, and our products contain squalane. It is an excellent moisturizer to help support the skin barrier and reduce dryness. Renowned for its lightweight, silky texture, it’s absorbed easily by skin. In fact, skin’s own natural oil is partially comprised of squalane, making it a perfect complement for your skin to embrace the benefits. It helps minimize moisture loss and gives a soft, supple feel to skin.

 

Awards & Honors

We're proud of all of our products and are committed to offering you only the highest-quality, most effective products – so we're very happy when others recognize our products and when our customers agree with us! Here are some of the awards and media mentions for this product.

Health Beauty Award Winner 2021
Mary Kay Clinical Solutions™ Retinol 0.5 Set

The Mary Kay Clinical Solutions Retinol 0.5 Set has earned the Health magazine Beauty Award Winner 2021. Amplify your age-fighting power to new levels.

Claims and Benefits

In an eight-week independent clinical study of Mary Kay Clinical Solutions™ Retinol 0.5,

  • 100% of women experienced improvement in skin smoothness.**
  • 100% of women experienced improvement in skin radiance.**

In addition, panelists experienced visible improvement in:

  • Wrinkles
  • Firmness
  • Skin tone evenness

In clinical testing of Mary Kay Clinical Solutions™ Calm + Restore Facial Milk, this fluid formula was shown to:

  • Calm irritated skin.
  • Deliver instant hydration.†

**Results based on an independent expert evaluator assessing 22 women during an eight-week clinical study in which women used Mary Kay Clinical Solutions™ Retinol 0.5 every other night for the first two weeks, then applied nightly weeks 3–8. Data reflects the percentage of panelists who showed improvement or the percentage of improvement for an attribute compared to baseline measurements taken at the beginning of the study.
Results based on two independent clinical studies in which women used the Mary Kay Clinical Solutions™ Calm + Restore Facial Milk
These products cannot be sold in the Dominican Republic due to local regulations.